Jing Huang1, Juan Wei2, and Jie Lu1
1Xuanwu Hospital, Capital Medical University, Beijng, China, 2GE Healthcare, MR Research, Beijng, China
1Xuanwu Hospital, Capital Medical University, Beijng, China, 2GE Healthcare, MR Research, Beijng, China
The amplitude of low frequency fluctuation
(ALFF) in middle temporal gyrus and middle frontal gyrus
might play important role in the prognosis of visual acuity in optic neuritis, which
might be used as a potential imaging marker
to predict the outcome of visual acuity.
The differences in
ALFF among three groups. G1: healthy control group, G2: ON patients with good visual outcome,
G3: ON patients with poor visual outcome. Significantly
decreased mALFF were observed in left cuneus and left middle occipital gyrus,
right paracentral lobule,
right anterior cingulate cortex, and
bilateral middle temporal gyrus, left middle frontal gyrus in ON
patients than HCs. While increased mALFF
were occurred in several
regions in the frontal and temporal lobes (P< 0.001, FDR corrected).
The correlations between the VA and ALFF in ON. The positive correlations were found
in bilateral
middle temporal gyrus and significantly negatively
related to ALFF in left middle frontal gyrus.