Paola Valsasina1, Laura Cacciaguerra1,2,3, Damiano Mistri1, Vittorio Martinelli2, Massimo Filippi1,2,3,4,5, and Maria A. Rocca1,2,3
1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy, 2Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, 3Vita-Salute San Raffaele University, Milan, Italy, 4Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, 5Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy
1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy, 2Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, 3Vita-Salute San Raffaele University, Milan, Italy, 4Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, 5Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy
In neuromyelitis optica
spectrum disorders, abnormal dynamic functional connectivity of the precuneus
with several cortico-subcortical regions was observed. Increased dynamic
functional connectivity correlated with depression and cognitive deficits.
Figure
1. Mean (A) and
standard deviation (B) of precuneus dyamic functional connectivity (dFC) across
windows in healthy controls (HC) and neuromyelitis optica spectrum disorder
(NMOSD) patients. Voxel-wise comparisons of standard deviation (C) between HC
and NMOSD (age- and sex-adjusted full factorial models). Significant results
are shown in red-yellow (NMOSD>HC) and blue-light blue (HC>NMOSD).
B=bilateral; L=left; R=right.