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Rich-club connectivity of the structural covariance network is reduced in mild cognitive impairment and Alzheimer’s disease
Gerhard Drenthen1, Walter Backes1, Whitney Freeze1, and Jacobus Jansen1
1Maastricht University Medical Center, Maastricht, Netherlands
A reduced rich-club connectivity of the structural covariance network is found in individuals with mild cognitive impairment and Alzheimer’s disease compared to controls. Moreover, this reduction is related to a loss of memory performance.
Figure 3: Boxplots of the rich-club coefficient for the three diagnostic groups.
Figure 2: The identified hub nodes in the structural covariance network; right middle temporal gyrus; right superior parietal gyrus; right pars triangularis; right lateral occipital gyrus; right fusiform gyrus; right precuneus; right posterior cingulate cortex; right cuneus; left middle temporal gyrus; left fusiform gyrus; left pars triangularis; left precentral gyrus; left posterior cingulate cortex; left superior parietal gyrus.