Development of a Clinical CEST-MR Fingerprinting (CEST-MRF) Pulse Sequence and Reconstruction Methods
Ouri Cohen1, Or Perlman2, Christian T Farrar2, and Ricardo Otazo1
1Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Radiology, Massachusetts General Hospital, Charlestown, MA, United States
A clinical CEST MR Fingerprinting pulse sequence is shown to simultaneously yield multiple accurate tissue parameter maps in a short scan time.
Figure
3: Reconstructed water relaxation (T1w, T2w), amide exchange rate (Ksw) and
volume fraction (fs) and semi-solid exchange rate (Kssw) and volume fractions
(fss) from an in vivo healthy subject imaged with the clinical CEST-MRF pulse
sequence.
Figure
1: Pulse sequence diagram for the proposed MRF-CEST sequence for one time step.
A gaussian-shaped pulse train saturates the amide proton which then exchange
with the water protons. The reduction in the water signal is measured with an
EPI readout