1537
Exploring cyto-architecture of Brodmann areas with High-resolution 3D MR Fingerprinting
Joon Yul Yul Choi1, Siyuan Hu2, Ting-yu Su1,2, Yingying Tang1, Ken Sakaie3, Ingmar Blümcke1,4, Imad Najm1, Stephen Jones3, Mark Griswold5, Dan Ma2, and Zhong Irene Wang1
1Epilepsy Center, Neurological Institue, Cleveland Clinic, Cleveland, OH, United States, 2Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 3Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 4Neuropathology, University of Erlangen, Erlangen, Germany, 5Radiology, Case Western Reserve University, Cleveland, OH, United States
We investigate T1 and T2 values in Brodmann areas of the normal brain using 3D magnetic resonance fingerprinting. Our results demonstrate the sensitivity of multi-parametric MRF results at 3T to differentiate cortical regions with different cyto- or myelo-architecture. 
Figure 2. Mean and standard deviation of MRF T1 and T2 values of gray matter in selected Brodmann areas. Paired t-test was performed between Brodmann areas 8 and the other areas. p* < 0.05
Figure 5. Correlation analyses between T1 and T2. Spearman’s correlation analysis was performed in each BA. Green: p* < 0.05, red: p > 0.05