Congyu Liao1, Xiaozhi Cao1, Ting Gong2, Zhe Wu3, Zihan Zhou2, Hongjian He2, Jianhui Zhong2,4, and Kawin Setsompop1
1Radiological Sciences Laboratory, Stanford University, Stanford, CA, United States, 2Center for Brain Imaging Science and Technology, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 3Techna Institute, University Health Network, Toronto, ON, Canada, 4Department of Imaging Sciences, University of Rochester, Rochester, NY, United States
1Radiological Sciences Laboratory, Stanford University, Stanford, CA, United States, 2Center for Brain Imaging Science and Technology, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 3Techna Institute, University Health Network, Toronto, ON, Canada, 4Department of Imaging Sciences, University of Rochester, Rochester, NY, United States
We developed a 3D ViSTa-MRF sequence with subspace
reconstruction, to achieve whole-brain myelin-water fraction (MWF) and T1/T2/PD
mapping at 1mm isotropic resolution in 10 minutes. The proposed method can
provide fast parametric mapping with high SNR and good image quality.
Whole-brain 1mm iso
T1/T2/PD/ViSTa and MWF maps in three orthogonal views.
Figure 1. (A) Sequence diagram of 3D ViSTA-MRF.
(B) extended phase graph (EPG) simulation of the first ViSTa signal. The myelin-water signal with short-T1
is preserved in the ViSTa signal while the white-matter (WM), gray-matter (GM)
and CSF are suppressed, which enables direct myelin-water imaging. (C)Simulated
signal curves of myelin-water, WM, GM and CSF for the ViSTa-MRF sequence. FA: flip angle.