Alessandra Caporale1, Michael Langham1, and Felix W Wehrli1
1Radiology, Laboratory for Structural, Physiologic and Functional Imaging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
1Radiology, Laboratory for Structural, Physiologic and Functional Imaging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
MRI metrics of peripheral, cerebrovascular reactivity and aortic stiffness were compared in smokers, vapers and nonsmokers (all<35y). No MRI metrics was significantly different among groups, likely because damage accumulation takes longer to elicit measurable effects on the endothelium.
Figure 2 – A. The cuff is proximal to the superficial femoral artery and vein. B. Artery lumen (At) is measured before cuff-occlusion and post-cuff release, to evaluate flow mediated dilation. C. Venous saturation (SvO2) is measured continuously post-cuff release (acquisition is interrupted 3 times to measure At), using the phase difference between vein (v.) and artery (a.) (SvO2b=pre-cuff SvO2; Tw=washout time). D. Arterial blood flow velocity averaged across the artery lumen, plotted vs time. (VP=peak velocity; HI=blood acceleration; TP=time to peak; TFF=hyperemia duration).
Figure 1 – Demographics, details on smoking/vaping history and exposure, and gender distribution in the three groups.
