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Developmental trajectories of cerebral blood flow and neurodevelopmental score in preterm children from 28 days to 13 years
Peiyao Chen1, Chao Jin1, Xianjun Li1, Miaomiao Wang1, Congcong Liu1, Xiaoyu Wang1, Fan Wu1, Yuli Zhang1, Cong Tian1, Mengxuan Li1, Xiaocheng Wei2, and Jian Yang1
1First Affiliated Hospital of Xi 'an Jiaotong University, Xi'an, Shaanxi, China, 2MR Research China, GE Healthcare, Beijing, China
Preterm children showed lower cerebral blood flow than term in the frontal lobe, even at late childhood. After controlling for age, CBF showed positive correlations with mental and psychomotor development indexes in left frontal and occipital lobes in preterm children.
Figure 1. Manual regions of interest (ROIs) were placed on the CBF map by using the aligned anatomical image as guidance. ROI was about 20-100mm2. (A) bilateral superior frontal gyrus and posterior central gyrus.(B)bilateral superior temporal gyrus.(C)bilateral occipital lobe.(D)basal ganglia (bilateral thalamus, globus pallidus, putamen, caudate nucleus)
Figure 4. Regions of positive correlation between MDI、PDI and CBF in preterm infants aged 60 days-4 years of age. MDI (pink): left frontal、occipital lobe and caudate nuclear. PDI (blue): left frontal and occipital lobe.