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Demyelination is related to deep gray matter iron deposition in CADASIL patients
hui hong1, shuyue wang1, xinfeng Yu2, Yererfan Jiaerken2, Xiaojun Guan2, and minming zhang2
1radiology, Zhejiang University, hangzhou, China, 2radiology, the second affiliated hospital of zhejiang university, school of medicine, hangzhou, China
Demyelination of white matter is associated with deep gray matter iron deposition in CADASIL patients.
Comparison of iron deposition between patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and healthy controls. Increased iron deposition of caudate, putamen, and pallium in patients with CADASIL compared with healthy controls. ns indicates nonsignificant. *A significant correlation (P<0.05).
Correlations between white matter microstructure and putamen iron deposition. FA: fractional anisotropy; MD: mean diffusivity; RD: radial diffusivity