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Resting-state functional connectivity and brain network abnormalities in depressive patients with suicidal ideation
Jun-Cheng Weng1,2,3, Yu-Syuan Chou4, Yuan-Hsiung Tsai5,6, and Vincent Chin-Hung Chen3,5
1Department of Medical Imaging and Radiological Sciences, and Bachelor Program in Artificial Intelligence, Chang Gung University, Taoyuan, Taiwan, 2Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, 3Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, 4Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan, 5School of Medicine, Chang Gung University, Taoyuan, Taiwan, 6Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan
Our results showed that lower activity in the thalamus and cuneus regions were related to suicidal ideation. The different topological organization and slightly worse local segregation of the brain network in suicidal ideation patients.
Figure 3. The NBS analysis results. A disrupted subnetwork was found in the SI group compared with the NS group (NS > SI).
Figure 1. (a) Two-sample t-test results of mfALFF between the SI and the NS groups (NS > SI, color bar represents t-score). (b) Lower mfALFF of the left cuneus and (c) higher mfALFF of the right middle temporal pole gyrus were found in the SI group compared with the NS group. (d) Two-sample t-test results of mReHo between the SI and the NS groups (NS > SI; color bar represents t-score). (e) Lower mReHo of the right cuneus and (f) higher mReHo of the left middle temporal gyrus (MTG) were found in the SI group compared with the NS group.