Jacques Andrew Stout1, Robert BJ Anderson2, Simon Wilton Davis3, Jie Zhuang3,4, David Dunson5,6, Heather Elisabeth Whitson7, and Alexandra Badea1,2,3
1BIAC, Duke School of Medicine, Durham, NC, United States, 2Duke Radiology, Duke School of Medicine, Durham, NC, United States, 3Duke Neurology, Duke School of Medicine, Durham, NC, United States, 4School of Psychology, Shanghai University of Sport, Shanghai, China, 5Statistics, Duke University, Durham, NC, United States, 6Trinity College of Arts & Sciences, Duke University, Durham, NC, United States, 7Geriatrics, Duke School of Medicine, Durham, NC, United States
1BIAC, Duke School of Medicine, Durham, NC, United States, 2Duke Radiology, Duke School of Medicine, Durham, NC, United States, 3Duke Neurology, Duke School of Medicine, Durham, NC, United States, 4School of Psychology, Shanghai University of Sport, Shanghai, China, 5Statistics, Duke University, Durham, NC, United States, 6Trinity College of Arts & Sciences, Duke University, Durham, NC, United States, 7Geriatrics, Duke School of Medicine, Durham, NC, United States
Macular Degeneration is associated with accelerated age-related decline (AMD). We therefore compared subjects with AMD to controls twice with a 2-year gap. We observed that FA decreased much faster in AMD subjects, and PCA over connectivity matrices determined the most affected connections.
Fig 2: Slices of T1 anatomical results, displaying areas of important FA differences between subjects with AMD and controls.
Top row: Results of VBA on anatomical images obtained upon initial scanning
Middle row: Results of VBA on anatomical images obtained two years later.
Bottom row: Location of important volumetric changes in subjects in the two-year interval.
Top row: Results of VBA on anatomical images obtained upon initial scanning
Middle row: Results of VBA on anatomical images obtained two years later.
Bottom row: Location of important volumetric changes in subjects in the two-year interval.
Fig 1: Slices of T1 anatomical results, displaying areas of important volumetric differences between subjects with AMD and controls.
Top row: Results of VBA on anatomical images obtained upon initial scanning.
Middle row: Results of VBA on anatomical images obtained two years later.
Bottom row: Location of important volumetric changes in subjects in the two-year interval.
Top row: Results of VBA on anatomical images obtained upon initial scanning.
Middle row: Results of VBA on anatomical images obtained two years later.
Bottom row: Location of important volumetric changes in subjects in the two-year interval.
