Jimin Ren1,2, Craig R Malloy1,2, and Dean Sherry1,2
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States
We presented solid evidence of large Pi line-broadening and splitting observed in human brain by 31P MRS at 7T. The effect may reflect pH heterogeneity in different brain tissues and/or cell types with distinct metabolism.
Fig1. 7T 31P MR spectrum acquired from the occipital-parietal region of a 30 years old female using a partial volume coil. Note that the intracellular Pi signal is split into two separate peaks with 0.1 ppm difference in chemical shift.
Fig 3. 7T 31P MR spectrum averaged over eight healthy subjects. The data were acquired from the posterior brain using a partial volume coil. Note that the nearly symmetric line-broadening at Pi in reference to PCr (blue trace).
