1819
MRI contrast agent for myocardial infarction based on novel manganese-based nanoparticles
Chengbin He1, Xiaoxuan Zhou1, Cailing Pu1, Jingle Fei1, Yan Wu1, and Hongjie Hu1
1Department of Radiology, Sir Run Run Shaw Hospital (SRRSH), Zhejiang University School of Medicine, Hangzhou, China
Our study found that BHMNP had high T1 relaxation rate and high signal intensity in the myocardial infarction area. In addition, BHMNP has the potential for clinical transformation due to its simple synthesis, good biocompatibility and biodegradability.

a. MRI images of mice injected with BHM;

b. TTC and HE staining;

c. CNR curves of BHM and Omniscan.

a.The particle size of BHM was about 67 nm.

b.The particles were regular and uniform spheres under transmission electron microscope