Ruiyang Zhao1,2, Jitka Starekova1, Scott B Reeder1,2,3,4,5, and Diego Hernando1,2
1Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 3Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 4Medicine, University of Wisconsin-Madison, Madison, WI, United States, 5Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States
1Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 3Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 4Medicine, University of Wisconsin-Madison, Madison, WI, United States, 5Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States
Optimized coronal and sagittal free breathing 2D FAM CSE techniques accurately map PDFF and R2* in the liver, while enabling free-breathing acquisitions with whole-liver coverage and without motion-related tissue slice gaps.
Figure 1. PDFF and R2* maps comparisons between scans with axial, coronal, and sagittal acquisitions using optimized CSE FAM sequences. The first row includes movies from real-time SGRE acquisition. The red arrow indicates the potential missing tissue in axial acquisition due to through-plane motion during free breathing. However, in both coronal and sagittal acquisitions, the liver is captured without obvious missing tissue while performing free breathing scanning (first row), which may enable whole-liver PDFF/R2* mapping while minimizing missed tissue (second/ third rows).
Figure 3. Bland-Altman plots between PDFF/R2* measurements from 2D CSE technique and FAM CSE technique with reference PDFF/R2* obtained from 3D CSE in all three acquisition directions (axial, coronal, and sagittal). Low bias in PDFF/R2*, with narrow limits of agreement are observed for both 2D CSE and FAM CSE.