Diana Bencikova1,2, Marcus Raudner1, Sarah Poetter-Lang1, Nina Bastati1, Ahmed Ba-Ssalamah1, Siegfried Trattnig1,2, and Martin Krššák2,3
1Department of Radiology, Medical University Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular Imaging, MOLIMA, Vienna, Austria, 3Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria
1Department of Radiology, Medical University Vienna, Vienna, Austria, 2Christian Doppler Laboratory for Clinical Molecular Imaging, MOLIMA, Vienna, Austria, 3Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria
The
goal of this study was to investigate the effect of hepatic fat accumulation on
water T2 values in phantoms and patients. MRS and MRI T2 mapping measurements
were analyzed. No significant influence of fat accumulation on in vivo T2
values in the range of hepatic FF ≤ 15% was detected.
Figure 2: Patient results. A: There is a statistically significantly strong correlation between HISTO MRS
T2 and FS rTSE T2 with r = 0.71, P < 0.0001. B: a statistically not
significant weak negative correlation between hepatic FF and HISTO MRS T2 with r
= -0.22, P = 0.0734 and C: a statistically not significant weak positive
correlation between FF and FS rTSE T2 with r = 0.11, P = 0.3617.
Figure 1: Phantom results. A:
HISTO MRS T2 values strongly correlate with FS rTSE T2 values. B: Systematic
difference between the two acquisitions can be observed. A decrease in T2
values can be detected with increasing FF up to 10 %, then the decrease levels
out. Phantom composition, as the samples were constructed in 50ml tubes with
the given FF filled up with MnCl2 solution, can be a potential explanation.
