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Non-Alcoholic Fatty Liver Disease: Association Between the Biomechanics and Inflammation Severity in Early-Stage Diffuse Liver Disease
Christian Simonsson1,2, Markus Karlsson1, Patrik Nasr3, Ralph Sinkus4, Simone Ignatova5, Nils Dahlström1, Mattias Ekstedt2,3, Stergios Kechagias3, and Peter Lundberg1,2
1Department of Radiation Physics, Radiology, Linköping University, Linköping, Sweden, 2Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 3Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, 4Imaging Sciences & Biomedical Engineering, Kings College London,, London, United Kingdom, 5Linköping University, Linköping, Sweden
We have shown correlations between 3D-MRE biomechanical properties (GI, α and cs) and histopathological features in a liver disease cohort, with patients expressing various degrees of hepatic inflammation. References
Fig 3. a) The tissue viscosity, GI , plotted against fibrosis labels and inflammation score. b) the shear wave absorption, α, plotted against fibrosis labels and inflammation score. c) shear wave speed, cs, plotted against fibrosis labels and inflammation score.
Fig 2. a) Anatomy and MRE transducer placement. b) ROI in magnitude image. c) shear wave speed, cs. d) shear wave absorption, α. e) tissue viscosity, GI. f) tissue elasticity Gabs.