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Disrupted resting-state salience network in type 2 diabetes with and without mild cognitive impairment
Yumeng Lei1, Dongsheng Zhang1, Fei Qi2, Man Wang2, Jie Gao1, Min Tang1, Yu Su2, Zhirong Shao2, Kai Ai3, and Xiaoling Zhang1
1Department of MRI, Shaanxi Provincial People’s Hospital, Xi'an, China, 2Xi'an Medical University, Xi’an, China, 3Philips Healthcare, Xi'an, China
As far as we known, this was the first study to discussed the different functional connectivity patterns in salience network (SN) of type 2 diabetes mellitus (T2DM), we found that the SN may have a dynamic change process from compensatory to decomposable in T2DM patients.
Fig1. Compared with HC, significant increases (warm color) in the resting-state functional connectivity of the SN in DMCN patients. (p < 0.05, GRF corrected)
Fig4. Correlations between the rsFC of the right FIC in the SN and the MoCA scores of T2DM patients (r = 0.334,P = 0.007)