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Study on the white matter integrity in T2DM using automated fiber quantification tractography

Jun Wang¹, Wenjuan Bai², Pengfei ZHANG¹, Wenjing HUANG¹, Wanjun HU¹, Guangyao LIU¹, and Jing ZHANG¹
¹Department of Magnetic Resonance, Lanzhou University Second Hospital, Lan Zhou, China, ²Second School of Clinical Medicine, Lanzhou University, Lan Zhou, China

The microstructural integrity of white matter (WM) was evaluated using automated fiber quantification tractography. AFQ demonstrated early significant white matter attracts differences between T2DM and HC groups. And these parameters may be used to distinguish T2DM from HC.

Fig. 1. Pointwise comparison of fractional anisotropy (FA) and mean diffusivity(MD) along the 20 WM tract among the type 2 diabetes (T2DM), and healthy controls (HC), which has a significant differences. The FA profiles are presented in mean ± standard deviation (SD). The red line stands for the T2DM , and blue for HC. The solid lines stand for the mean values and the shaded areas for SD. The horizontal axis indicates the location between the beginning and termination waypoint region of interest along the given tract. L (R), left (right) hemisphere.

Fig. 3. The receiver operating characteristic analysis of group classification using support vector machine