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Early Detection of Type 2 Diabetes Mellitus with Mild Cognitive Impairment based on Multiple Advanced Diffusion Models: DKI, MAP-MRI and NODDI
Wen-jiao Lyu1, Yunzhu Wu2, Xiao-meng Ma1, Yue Feng1, Yu-na Chen1, Shi-jun Qiu1, Xu Yan2, Min-xiong Zhou3, and Guang Yang4
1Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China, 2MR Scientific Marketing, SIEMENS Healthcare, Shanghai, China, 3Shanghai University of Medicine & Health Sciences, Shanghai, China, 4Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China
MAP-, NODDI-, DKI-based diffusion parameters could be used as potential biomarkers for early detection and differential diagnosis of T2DM patients with or without mild cognitive impairment.
Figure 2. The diffusion parameter maps from MAP-MRI, NODDI, and DKI for a T2DM patient.
Table 1. Independent student's T-test analysis among T2DM_MCI, T2DM_UCI, and healthy control groups in pairs