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31P MRS and MRI phenotyping of muscle metabolic quality in Inflammatory Bowel Disease fatigue
Jordan J McGing1,2,3, Rosemary Nicholas2, Sébastien Serres4, Paul L Greenhaff5,6,7, Gordon W Moran1,7, and Susan T Francis2
1Nottingham Digestive Diseases Centre, Queens Medical Centre, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Centre, Nottingham, United Kingdom, 3School of Medicine, University of Nottingham, Nottingham, United Kingdom, 4School of Life Sciences, University of Nottingham, Nottingham, United Kingdom, 5MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, Nottingham, United Kingdom, 6Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, Nottingham, United Kingdom, 7National Institute of Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham, United Kingdom
Fatigue aetiology is unknown in IBD although muscular performance deficits suggest a peripheral origin. A 31P MRS experiment revealed a reduced oxidative capacity in fatigued IBD patients relative to healthy controls, which may be restored by suggesting exercise training intervention.
Figure 2: Experimental protocol (A) baseline familiarisation and strength assessment. (B) 1H mDIXON scans to image calf and quantify whole muscle volume and % fat fraction. (C) Non-localised pulse-acquired 31P MRS protocol involving continuous 31P spectra acquisition during the resting state, transition into ischemic plantar flexion exercise and subsequent non-ischemic exercise recovery following release of blood pressure cuff.
Figure 5 : Post exercise PCr recovery kinetics (Mean ± SEM).