Maurizio Bergamino1, Elizabeth G Keeling1,2, Ryan R Walsh3, and Ashley M Stokes1
1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2School of Life Sciences, Arizona State University, Tempe, AZ, United States, 3Muhammad Ali Parkinson Center at Barrow Neurological Institute, Phoenix, AZ, United States
1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2School of Life Sciences, Arizona State University, Tempe, AZ, United States, 3Muhammad Ali Parkinson Center at Barrow Neurological Institute, Phoenix, AZ, United States
We demonstrated sexual dimorphism in AD subjects in FW and FA metrics, as well as GM volumes. Sex differences must be considered in the development of novel therapies for AD, as well as in the interpretation of brain imaging findings in AD cohorts.
Effect-size from ANCOVA for main effects of group and sex. The results are shown at a large-effect size level for the main effect of group and medium effect-size level for the main effect of sex. *FW index did not show any significant cluster at large effect-size level. The violin plots show the mean values of each metrics inside the significant clusters. No significant difference across groups was found for the interaction term.
Effect-size from post-hoc comparison between females and males inside AD and HC groups. We found significant sexual dimorphism at large effect-size level inside the AD group by all metrics. In HC group, only VBM detected differences between females and males at the large effect-size level. *FA and FW index, for HC group, detected differences only at medium effect-size level. Males showed higher FA, higher FW index, and lower GM volumes than females in AD group.