1912

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Alterations and associations between magnetic susceptibility of the basal ganglia and diffusion properties in Alzheimer's disease

Xiuxiu Liu¹, Lei Du^1,2, Wenwen Gao¹, Bing Liu^1,2, Yue Chen¹, Yige Wang^1,2, Guolin Ma¹, and Weiyin Liu³
¹Department of Radiology, China-Japan Friendship Hospital, Beijing, China, ²Graduate School of Peking Union Medical College, Beijing, China, ³GE Healthcare, Beijing, China

This study revealed that diffusion function and the magnetic susceptibility of the basal ganglia changed in Alzheimer's patients, and these changes were related to cognitive decline. In addition, iron deposition overload may adversely affect the dispersion function of white matter fibers.

Brain clusters showed AxD differences between AD group and HC group after FWE correction.

Correlations between diffusion indexes and cognitive scores in Alzheimer’s patients.