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Neurite dispersion and density across the adult lifespan investigated using a modified NODDI approach
Maryam H. Alsameen1, Wenshu Qian1, Matthew Kiely1, Curtis Triebswetter1, Zhaoyuan Gong1, and Mustapha Bouhrara1
1National Institute on Aging, NIH, Baltimore, MD, United States

·       NODDI overestimates CSF and NDI values.

·       Our modified NODDI approach addresses this concern and provides realistic NDI values.

·       NDI and ODI follow quadratic associations with age in most white matter regions.

 

Figure 5. Significance of each coefficient incorporated into the linear regression analysis of NDI or ODI derived from NODDI or modified NODDI in each region-of-interest (ROI). * indicates p < 0.05, ** indicates p < 0.01, + indicates p < 0.1, and - indicates non-significant effects. All p-values presented are obtained after FDR correction.

Figure 4. Examples of regional ODI trends as a function of age. A) ODI results derived from the original NODDI approach, and B) ODI results derived using our modified NODDI approach. Several regions investigated show U-shaped trends of ODI with age. Results were very similar for both NODDI approaches (see Fig. 5).