Abdur Raquib Ridwan1, Yingjuan Wu1, Mohammad Rakeen Niaz1, David A. Bennett2, and Konstantinos Arfanakis1,2
1BIOMEDICAL ENGINEERING, ILLINOIS INSTITUTE OF TECHNOLOGY, Chicago, IL, United States, 2Rush Alzheimer’s Disease Center, RUSH UNIVERSITY MEDICAL CENTER, Chicago, IL, United States
1BIOMEDICAL ENGINEERING, ILLINOIS INSTITUTE OF TECHNOLOGY, Chicago, IL, United States, 2Rush Alzheimer’s Disease Center, RUSH UNIVERSITY MEDICAL CENTER, Chicago, IL, United States
A minimum deformation T1w template of the older adult brain minimizes bias, and sparse, patch-based template construction preserves details which allows for least deformation and high spatial normalization accuracy of older-adult brains.
Fig. 1: Schematic of the template construction technique.
Fig. 3: A) Example axial, sagittal and coronal slices of the new template, MCALT_0.5mm, ICBM2009b_0.5mm, Colin27_0.5mm and HCP_0.5mm templates. B) Atypical anatomical features can be observed in the cortex of MCALT_0.5mm (red circles). C) Normalized power spectra of all templates.
