Junjie Wu1, Syed S. Shahid2,3, Qixiang Lin2, Antoine Hone-Blanchet2, Jeremy L. Smith1, Benjamin B. Risk4, Aditya S. Bisht2, David W. Loring2, Felicia C. Goldstein2, Allan I. Levey2, Bruce A. Crosson2,5, James J. Lah2, and Deqiang Qiu1,6
1Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 2Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States, 3Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 4Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA, United States, 5Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, GA, United States, 6Joint Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States
1Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 2Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States, 3Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 4Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA, United States, 5Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, GA, United States, 6Joint Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States
Normal aging affects functional connectivity and microstructure in all hippocampal subfields while the subiculum and CA1-3 exhibit the greatest sensitivity to pathological aging. The imaging measures correlate with neuropsychological performance and tau.
Fig 4. Group differences of functional connectivity in the subiculum, CA1-3 and CA4-DG networks between healthy older adults with negative CSF biomarker status (HO-) and positive CSF biomarker status (HO+). Significant at *P < 0.05.
Fig 5. Correlations of imaging measures with neuropsychological performance (A) and CSF biomarker measurements (B). The fitting lines are also shown to indicate trends.
