Maurizio Bergamino1, Ryan R Walsh2, and Ashley M Stokes1
1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Muhammad Ali Parkinson Center at Barrow Neurological Institute, Phoenix, AZ, United States
1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Muhammad Ali Parkinson Center at Barrow Neurological Institute, Phoenix, AZ, United States
Using a novel and robust analysis of multi-shell diffusion data, we demonstrated significant alterations in structural connectivity and white matter integrity in MCI subjects. We anticipate these methods may be useful neuroimaging biomarkers in MCI.
Connectometry analysis detected differences in structural connectivity between HC and MCI in two distinct tracts: one between the left-lateraloccipital and the left-insula, which includes part of the left IFOF and the left ILF, and one between the left-precuneus and the left-supramarginal, which includes part of the left superior-longitudinal fasciculus. The yellow circles in the HC-MCI p-values connectometry matrix show the significant edges with p<0.05.
Voxel-based analysis of FA, IC, ISO, and EC maps. Lower values of FA in the MCI group, compared with HCs, were found in the fornix. Lower IC and higher ISO values were found in MCI in several white matter regions and tracts. No significant differences between groups, at p<0.05, were found for the EC metric.