1931
Impact of Dementia with Lewy Bodies on Brain Biomechanical Properties
KowsalyaDevi Pavuluri1, John Huston III1, Richard L. Ehman1, Armando Manduca1,2, Clifford R. Jack Jr1, Rodolfo Savica3, Bradley F Boeve4, Kejal Kantarci1, David S Knopman3, Ronald C. Petersen3, and Matthew C. Murphy1
1Department of Radiology, Mayo Clinic, Rochester, MN, United States, 2Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, United States, 3Department of Neurology, Mayo Clinic, Rochester, MN, United States, 4Division of Pulmonary and Critical Care Medicine, Mayo Center for Sleep Medicine, Mayo Clinic, Rochester, MN, United States
To investigate the impact of Dementia with Lewy bodies (DLB) on brain viscoelasticity and assess the feasibility of mechanical properties as potential biomarkers of DLB.
Figure 2. Neural network inversion calculated mean stiffness maps for two groups controlling for age and sex. Each column indicates an image from different slice locations, MNI coordinates are arranged from inferior to superior positions.
Figure 3. Neural network inversion calculated mean damping ratio maps for two groups after correction for age and sex. Each column indicates an image from different slice locations MNI coordinates are arranged from inferior to superior positions.