Harish Palnitkar1, Shreyan Majumdar2, Rolf Reiter3, Shujun Lin2, Joseph Crutison2, Thomas Royston2, and Dieter Klatt2
1Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL, United States, 2Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, 3Charite Universitatsmedizin, Berlin, Germany
1Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL, United States, 2Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, 3Charite Universitatsmedizin, Berlin, Germany
In prior investigations, we have established 1-Norm as quantitative measure of degree of inhomogeneity of biological tissues. Here, we apply 1-Norm to study effect of Alzheimer’s disease on mechanical inhomogeneity of brain. We aim to establish 1-Norm as biomarker to detect AD in humans.
Figure 2. Complex wave images (real part) for control
brain (top row) and brain of 5xFAD AD mouse model (bottom row), along with the
delineated contour of zero displacement shown in white color.
Figure 1. Representative block
diagram of the Magnetic Resonance Elastography (MRE) experimentation set-up.
