Forough Sodaei1,2, Jafar Zamani1,3, Maryam noroozian4, and Hamidreza Saligheh Rad1,5
1Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), 2Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), 3Department of Electrical Engineering, Iran University of Science and Technology, Tehran, Iran (Islamic Republic of), 4Memory and Behavioral Neurology Department, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), 5Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran, Iran (Islamic Republic of)
1Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), 2Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), 3Department of Electrical Engineering, Iran University of Science and Technology, Tehran, Iran (Islamic Republic of), 4Memory and Behavioral Neurology Department, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), 5Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran, Iran (Islamic Republic of)
Morphologic alterations of AD have been conventionally associated with the cerebral cortex; however, it is clear that other areas of the brain, especially the hippocampus are also involved. These structures, together with white matter structures including fornix constitute the limbic system, which is anatomic substrate of the memory system. Neurodegeneration in these areas lead to clinical manifestation of AD. In this study, we evaluated integrity of the limbic-associated areas in three groups using DTI. Findings yielded that the DTI-derived indices of the limbic-associated areas offer potential biomarkers for early and differential diagnosis of AD.
Clinical and demographic data of participants
Fig. 1 The parcellation map with ROIs of the limbic-associated areas overlaid on DTI-derived maps.