SLOW: Whole Brain Spectral Editing EPSI Based Technique using Chemical Selective Adiabatic 2π-Refocusing Pulses applied to 2HG and GABA Editing
Guodong Weng1, Claus Kiefer1, Irena Zubak2, and Johannes Slotboom1
1Institute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland, 2Department of Neurosurgery, Inselspital Bern and University Hospital, Bern, Switzerland
A new spectral editing scheme was developed in EPSI sequence for whole brain MRSI at 7T, which is B1-insensitive and has shown its capability to be an alternative method for MEGA editing.
Figure
1:
EPSI-SLOW spectral editing sequence scheme. a) Chemical selectively
refocusing the full range of interested spins. b) Chemical selectively
refocusing the partial range of interested spins.
Figure 2: a)
Simulation of the adiabatic pulse (used as inversion pulse in the simulation for
simplicity). The passband and transition band are indicated by blue/orange and
light blue/orange respectively for editing full and editing partial pulses. b)
The editing full/partial pulse bandwidth is 840 Hz but with a different carrier
frequency. TR = 1500 ms, volume of interest (VOI) = 280 X 220 X 100 mm, voxel
size = 4.3 X 11 X 13.8 mm, and total measurement time = 6 mins.