Sofie Tapper1,2, Muhammad G. Saleh3, Helge J. Zöllner1,2, Steve C.N. Hui1,2, and Richard A.E. Edden1,2
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States
Long-TE mixed flip angle (MFA) editing for GABA detection was implemented and validated using phantom- and one in vivo measurement. The preliminary results show potential for further work where the GABA-editing selectivity could be increased by allowing for longer editing pulse duration.
Figure 4. Resulting water-scaled in vivo difference spectra.
Figure 2. Simulations compared to Phantom measurements. For visualization purposes, the simulated data have been line-broadened to match the linewidth of the difference spectrum for the phantom data.