Michal Považan1, Michael Schär1, Joseph S Gillen1,2, and Peter B Barker1,2
1Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Kennedy Krieger Institute, F. M. Kirby Research Center for Functional Brain Imaging, Baltimore, MD, United States
1Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Kennedy Krieger Institute, F. M. Kirby Research Center for Functional Brain Imaging, Baltimore, MD, United States
Novel method for mapping proton downfield
resonances on a 3T scanner using 2D 1H-MRSI in combination with binomial
spectral-spatial excitation and selective refocusing.
Fig.1
– A – 2D Spin echo MRSI sequence with binomial spectro-spatial
excitation (red) and selective refocusing (green). B – Placement of the MRSI
FOV in vivo.
Fig.
4 – An
example of MRSI downfield spectra from three subjects shown for grey-matter
rich (red voxel) and white-matter rich (white voxel) voxels. 3Hz Gaussian
line-broadening was applied. Spectral pattern consists of resonances at 6.1,
6.8, 7.1, 7.3, 7.5, 7.9 and 8.2 ppm peaks.
