Jess E Reynolds1,2, Emma Tarasoff3, R Marc Lebel1,4, Bryce L Geeraert1, and Catherine Lebel1
1Department of Radiology, University of Calgary, Calgary, AB, Canada, 2Telethon Kids Institute, The University of Western Australia, Perth, Australia, 3Department of Neuroscience, University of Calgary, Calgary, AB, Canada, 4GE Healthcare, Calgary, AB, Canada
1Department of Radiology, University of Calgary, Calgary, AB, Canada, 2Telethon Kids Institute, The University of Western Australia, Perth, Australia, 3Department of Neuroscience, University of Calgary, Calgary, AB, Canada, 4GE Healthcare, Calgary, AB, Canada
NODDI and qiHMT
metrics demonstrate that white matter development during early childhood is
dominated by increasing axon density, alongside ongoing myelination and
slightly decreasing axon coherence.
Figure 1. Relationships between age and NDI are shown for all tracts. Linear fit
lines for the entire dataset are shown in black (where there is no significant
age*sex interaction) or red and blue (separated for females and males, where
there is a significant age*sex interaction). Linear fit lines for each
individual subject are shown in thinner red (girls) and blue (boys) lines.
Individual data points are shown in grey. Significance of linear age term *** p
< 0.001, ** p < 0.01, * p < 0.05
Figure 3. Relationships between age and qihMT (1/ms) are shown for all tracts. Linear fit
lines for the entire dataset are shown in black (where there is no significant
age*sex interaction) or red and blue (separated for females and males, where
there is a significant age*sex interaction). Linear fit lines for each
individual subject are shown in thinner red (girls) and blue (boys) lines.
Individual data points are shown in grey. Significance of linear age term *** p
< 0.001, ** p < 0.01, * p < 0.05
