Elizabeth Weiss1, Kelly Jarvis1, Chris Malaisrie2, Patrick McCarthy2, Robert Bonow3, James Carr1, Cynthia Rigsby4, and Michael Markl1
1Radiology, Northwestern University, Chicago, IL, United States, 2Cardiothoracic Surgery, Northwestern University, Chicago, IL, United States, 3Cardiology, Northwestern University, Chicago, IL, United States, 4Radiology, Lurie Children's Hospital, Chicago, IL, United States
1Radiology, Northwestern University, Chicago, IL, United States, 2Cardiothoracic Surgery, Northwestern University, Chicago, IL, United States, 3Cardiology, Northwestern University, Chicago, IL, United States, 4Radiology, Lurie Children's Hospital, Chicago, IL, United States
In bicuspid aortic valve patients with aortic dilation, mean reverse flow in the ascending aorta (AAo) and in the arch are elevated along with reverse flow volume. Mean reverse flow in the AAo and reverse flow volume were correlated with mid-ascending aorta diameter.
Figure 3. Comparison of reverse flow
metrics between healthy controls and BAV patients revealing increased reverse
flow and reverse flow volume in BAV patients. Asterisk indicates p-value < 0.05, red crosses are outliers,
and upper/lower bars denote the range within 1.5*interquartile range. (a) Mean
reverse flow in the AAo, (b) mean reverse flow in the arch, (c) mean reverse
flow in the DAo, (d) mean volume above 0.03mL/cycle, and (e) mean fraction of the AAo
occupied by reverse flow volume.
Figure 1. Analysis Work-flow. Centerlines
were automatically calculated for each segmented aorta (a) and planes were
placed to select the regions of interest (ROIs) (b). Orthogonal planes were
placed along the centerline for voxel-wise reverse flow calculations (c) to
generate reverse flow maps and mean intensity projections for each patient (d).
The threshold of 0.03mL/cycle was applied to each map to calculate reverse flow
volume (e).
