Muhammad G Saleh1, Steve Hui2, Helge Zöllner2, and Richard A Edden2
1University of Maryland School of Medicine, Baltimore, MD, United States, 2The Johns Hopkins University School of Medicine, Baltimore, MD, United States
1University of Maryland School of Medicine, Baltimore, MD, United States, 2The Johns Hopkins University School of Medicine, Baltimore, MD, United States
MEGA-PRESS editing of Phosphorylethanolamine/ethanolamine was successfully demonstrated at both 3.22 and 3.98 ppm. In vivo experiments show that the 3.22 ppm signal is better resolved and yield reproducible quantification.
Figure 2: In vivo MEGA-PRESS experiments at TE 90 and 110 ms for editing the PE3.22 (left) and PE3.98 (right). NAA: N-acetylaspartate; Lac: lactate; Cho: choline; and Cr: creatine.
Figure 3: Linear-combination modeling of PE3.22 and PE3.98 difference spectra with complete fit (yellow), spline baseline (black), and PE estimates at both TEs 90 ms (blue) and 110 ms (red). Asp: aspartate, Cho: choline, Cr: creatine, Gln: glutamine, Ins: myo-Inositol, Lac: lactate, MM: macromolecules, Tau: taurine.