Kiwamu Matsuoka1,2, Yuhei Takado1, Kenji Tagai1, Manabu Kubota3, Yasunori Sano1, Keisuke Takahata1, Maiko Ono1, Chie Seki1, Hideki Matsumoto1,4, Hironobu Endo1, Hitoshi Shinotoh1, Jamie Near5, Kazunori Kawamura1, Ming-Rong Zhang1, Hitoshi Shimada1, and Makoto Higuchi1
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, 2Department of Psychiatry, Nara Medical University, Kashihara, Japan, 3Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan, 4Department of Oral and Maxillofacial Radiology, Tokyo Dental College, the city of Chiyoda-ku, Japan, 5Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montréal, QC, Canada
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, 2Department of Psychiatry, Nara Medical University, Kashihara, Japan, 3Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan, 4Department of Oral and Maxillofacial Radiology, Tokyo Dental College, the city of Chiyoda-ku, Japan, 5Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montréal, QC, Canada
This multi-modal imaging study of tau aggregates
and antioxidant glutathione using tau PET and magnetic resonance
spectroscopy revealed associations of apathy
in progressive supranuclear palsy with tau aggregates and oxidative stress.
Representative
spectrum in the ACC and PCC. Volumes of interest of magnetic
resonance spectrum were placed at the ACC and PCC. A representative
MRS acquired with the SPECIAL sequence, the corresponding LCModel spectral fit,
fit residual, macromolecules (MM), baseline and individual metabolite fits
including GSH in the ACC and PCC.
a) Sagittal,
coronal, and transverse brain views showed voxels with positive associations between apathy scale scores and 18F-PM-PBB3
SUVRs
in patients with PSP after controlling for the effects of age and PSPRS. b, c)
Scatterplots showing the association between apathy scale scores and 18F-PM-PBB3
SUVRs in the detected areas (AG).
