Constrained Optimized Water Suppression (COWS) for 1H Magnetic Resonance Spectroscopy
Karl Landheer1, Martin Gajdošík1, and Christoph Juchem1,2
1Biomedical Engineering, Columbia University, New York City, NY, United States, 2Radiology, Columbia University, New York City, NY, United States
A novel algorithm for water
suppression was introduced and validated, which can accommodate an arbitrary
number of pulses, minimum durations between pulses, total module duration and
maximum flip angles.
Figure
3: Metabolite spectra obtained from the occipital lobe (top row) and
parietal lobe (bottom row) for the three water suppression schemes tested here,
VAPOR, COWS(7;236) and COWS(12;626). COWS(7;236) has comparable performance to
VAPOR, while COWS(12;626) has marked improvement over both. Note that WS
schemes were applied as theoretically optimized and no experimental fine tuning
was performed.
Figure
4: Macromolecule spectra obtained from the parietal lobe for VAPOR (red)
and COWS(7;236) (black). Marked reduction of residual water for COWS(7;236) was
observed over VAPOR. COWS(12;626) was not used due to its interference with the double
inversion preparation module.