Samuel W. Holder1,2, Michael Graham Harrington3, and Samuel Colles Grant1,2
1National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 2Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States, 3Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA, United States
1National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 2Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States, 3Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA, United States
Relaxation-enhanced
MRS at 21.1 T evaluated spontaneous trigeminal allodynia (STA) in the female
rat thalamus with and without nitroglycerin-induced sensitization. STA impacts the
buildup of naïve Glx signal but is reversed with nitroglycerin.
Figure 3: Temporal Glx increases
are observed in saline-injected STA animals, showing both between group and baseline significance. Baseline
significance begins 75 min post-injection, slightly before behavioral migraine
symptoms present in the nitroglycerin (NTG) group. NTG (10 mg/mg) was injected
at t=0 min. Brackets indicate significance between groups (p<0.05); * is
significance to baseline (p<0.05).
Figure 2: Periorbital
Von Frey mechanical sensitivity thresholds (force based on filament stiffness) for both (a) Naturally Resilient
(NR) and (b) Spontaneous Trigeminal Allodynic (STA) rats
