Layla Tabea Riemann1, Christoph Stefan Aigner1, Ralf Mekle2, Sebastian Schmitter1, Bernd Ittermann1, and Ariane Fillmer1
1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig und Berlin, Germany, 2Center for Stroke Research Berlin, Charité Universitätsmedizin, Berlin, Germany
1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig und Berlin, Germany, 2Center for Stroke Research Berlin, Charité Universitätsmedizin, Berlin, Germany
This work shows
improved repeatability and smaller CRLBs employing gradient-modulated adiabatic
inversion pulses compared to the hyperbolic secant pulse that was originally
used in the SPECIAL sequence for in-vivo 1H brain MRS at 7T.
Fig.2: a) Measured spectra between 0.0 and 4.2 ppm for
all pulses from session 1_1 for subject 2 b) Bland-Altman plots for HS (blue), GOIA
(orange), WURST (green) for R0 (top), R1,M (middle), and R1,W
(bottom) to visualize repeatability (R0) and
reproducibility (R1,M and R1,W). One point is
generated by using the two equations in the main text. The SD indicates the measure of repeatability/reproducibility and is, averaged over all pulses: 0.016, 0.039, and 0.064 for R0, R1,M and R1,W, respectively.
Fig.1:
a) Pulse diagram of SPECIAL with the HS (blue), GOIA
(orange), and WURST (green) pulse; b) Scan scheme (exemplary): 1. day 1. session
SPECIAL with HS, GOIA, and WURST; After repositioning the volunteer (1_2), scans
were repeated as in 1_1. 2. day scans (i.e., one week later) 1. session, HS, and
GOIA twice without repositioning. 2. session 2. day, WURST-SPECIAL twice without
repositioning. c) Exemplary voxel position in the posterior cingulate cortex (PCC) of a volunteer.
