Alexey Yakovlev1,2,3, Andrei Manzhurtsev1,3, Petr Menshchikov3,4, Maxim Ublinskiy3, Tolib Akhadov1, and Natalia Semenova1,2,3
1Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation, 2N.N.Semenov Federal research center of Chemical Physics Russian Academy of Sciences, Moscow, Russian Federation, 3N.M. Emanuel Institute of Biochemical Physics RAS, Moscow, Russian Federation, 4Philips Healthcare, Moscow, Russian Federation
1Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation, 2N.N.Semenov Federal research center of Chemical Physics Russian Academy of Sciences, Moscow, Russian Federation, 3N.M. Emanuel Institute of Biochemical Physics RAS, Moscow, Russian Federation, 4Philips Healthcare, Moscow, Russian Federation
We assessed a time for glutamate neurotransmitter release, reuptake, and refilling in vesicles. Early growth of Glx doesn't correlate with the maximum of BOLD response. For the first time, we investigated the dynamics of the BOLD-effect using the metabolic signal.
Figure 2. The paradigm of the visual stimulation: 3 s - a checkerboard flickering with a frequency of 4 Hz and 21 s - dark screen; scheme of fMRI and 1H MRS data acquisition during stimulus presentation.
Figure 1.T1-weighted image slices showing the voxel position for the single voxel spectroscopy in the activated visual cortex