Kathryn Y. Manning1,2,3, Xiangyu Long1,2,3, Lianne Tomfohr-Madsen2,4,5, Gerald Giesbrecht2,4,5,6, and Catherine Lebel1,2,3
1Radiology, University of Calgary, Calgary, AB, Canada, 2Alberta Children's Hospital Research Institute, Calgary, AB, Canada, 3Hotchkiss Brain Institute, Calgary, AB, Canada, 4Psychology, University of Calgary, Calgary, AB, Canada, 5Pediatrics, University of Calgary, Calgary, AB, Canada, 6Community Health Sciences, Calgary, AB, Canada
1Radiology, University of Calgary, Calgary, AB, Canada, 2Alberta Children's Hospital Research Institute, Calgary, AB, Canada, 3Hotchkiss Brain Institute, Calgary, AB, Canada, 4Psychology, University of Calgary, Calgary, AB, Canada, 5Pediatrics, University of Calgary, Calgary, AB, Canada, 6Community Health Sciences, Calgary, AB, Canada
We investigated the effects of prenatal psychological distress in pregnant Canadian mothers during the COVID-19 pandemic on the developing infant brain. Relatively less mature tracts and lower amygdala-prefrontal functional connectivity were related to higher prenatal distress.
Figure 2: The average amygdala functional connectivity across all subjects coloured by z-statistic.
Figure 5: The relationship between the PROMIS maternal anxiety measures and infant amygdala-prefrontal functional connectivity.
