Meher R. Juttukonda1,2, Randa Almaktoum1, Kimberly A. Stephens1, Kathryn Yochim1, Essa Yacoub3, Randy L. Buckner4, and David H. Salat1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Radiology, Harvard Medical School, Boston, MA, United States, 3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 4Psychology, Harvard University, Cambridge, MA, United States
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Radiology, Harvard Medical School, Boston, MA, United States, 3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 4Psychology, Harvard University, Cambridge, MA, United States
We propose a novel approach for measuring white
matter ATTs from multi-PLD ASL data. Using this approach, we demonstrated that
CBF is lower (and decreases with age) and ATT is longer (and elongates with age)
in white matter compared to gray matter.
Figure 2: (A) CBF is, overall, inversely associated with age
in both gray matter and white matter. (B) ATT is directly associated with age in both gray
matter and white matter. However, these
relationships may be different when comparing early to late middle-age adults
to older adults.
Figure 3: (A) The ratio of gray-to-white matter CBF generally
decreases with age until the fourth quartile in which there is more
variability. (B) The ratio of gray-to-white matter ATT also increases with age
and also exhibits greater variability in the fourth quartile.