Xingfeng Shao1, Chenyang Zhao1, Matthew Borzage2, Catherine Mark3, Elizabeth Joe4, Jonathan Russin3,5, Charles Liu3,4,5, Darrin Lee3,5,6, and Danny JJ Wang1,4
1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 3Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 4Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 5USC Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 6Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Fetal and Neonatal Institute, Division of Neonatology, Children's Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 3Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 4Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 5USC Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 6Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
An high spatiotemporal resolution ASL sequence and a denoising method were developed to measure dynamic choroid plexus (CP) perfusion. CP blood flow was altered in normal pressure hydrocephalus patient and has a potential relation with water exchange rate across the blood-brain barrier.
Figure 3. MPRAGE and perfusion map from one healthy subject (a) and NPH patient (b). CP was indicated by red arrows. Enlarged ventricle as well as choroid plexus hyperplasia can be observed in the NPH patient. (c) and (d) show scatter plot of average perfusion signal and fitted curves in GM and CP averaged across four healthy subjects and in the NPH patient, respectively. A delayed peak with comparable signal intensity was observed in CP as compared to GM in healthy subjects, while overall CP flow signal was relatively higher than GM in the NPH patient.
Figure 2. A center slice of perfusion image acquired at fifteen PLDs through direct subtraction (a) and KWIA filtering (b). CP was indicated by red arrows.
