Lara M Fahmy1, Yongsheng Chen2, Stephanie Xuan3, E Mark Haacke3, Jiani M Hu3, and Quan Jiang4
1Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States, 2Neurology, Wayne State University School of Medicine, Detroit, MI, United States, 3Radiology, Wayne State University School of Medicine, Detroit, MI, United States, 4Neurology, Henry Ford Health System, Detroit, MI, United States
1Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States, 2Neurology, Wayne State University School of Medicine, Detroit, MI, United States, 3Radiology, Wayne State University School of Medicine, Detroit, MI, United States, 4Neurology, Henry Ford Health System, Detroit, MI, United States
Our findings indicate that all peri-neural spaces surrounding all the cranial & spinal nerves & all peri-vascular spaces surrounding MRI-visible vasculature were filled with CSF; warranting further investigation into its cerebral waste clearance & immunomodulation implications.
Figure 4. Illustration showing that all MRI-visible vasculature were surrounded by CSF. A) sT2W image with bright CSF and dark blood; B) T1W with bright blood signal but dark CSF signal; C) CSF-only images, acquired by T2-TSE sequence with TE = 345ms at 3T; D) a 3D rendering of the CSF-only images. A) and B) were results from the high-resolution STAGE scans. The enlarged image in C) shows several MRI-visible vasculature (dark curves) surrounded by bright CSF. Images were generated from the second experiment as described in the method section.
Figure 1. CSF-filled peri-neural spaces surrounding the first five cranial nerves (CN I-CN V). A) Olfactory nerves (CN I); B) Optic nerves (CN II); C) Oculomotor nerves (CN III); D) Right trochlear nerve (CN IV); E) Left CN IV; and F) Trigeminal nerves (CN V). Space within the yellow lines: respective nerve (hypointense signal). Space between the red and yellow lines: peri-neural space (hyperintense signal). Space between the blue lines: CN V (hypointense signal). All images were generated from the first experiment as described in the method section.
