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Optimised framework for myelin water imaging: data post-processing and Bayesian regression
Ivan Maximov1,2, Oliver Geier3, Elias Kellner4, Helle Pfeiffer3, Valerij G Kiselev4, and Marco Reisert4
1Western Norway University of Applied Sciences, Bergen, Norway, 2NORMENT, University of Oslo, Oslo, Norway, 3Oslo University Hospital, Oslo, Norway, 4University Medical Center Freiburg, Freiburg, Germany

Myelin water imaging pipeline

Bayesian regression for a fast myelin water imaging

Figure 3 The resulting scalar maps obtained from the Bayesian regression and non-negative least squares approach. In Bayesian algorithm: v1 is the myelin water fraction, v2 and v3 are the fractions of intra- and extra-axonal water and contamination by CSF, respectively. The relaxation times are presented by TM, TA, and TCSF, respectively.
Figure 1 Algorithmic workflow of the optimised pipeline. The pipeline consists of four steps: noise correction of T2 weighted images, Gibbs-ringing correction, normalisation and smoothing of all volumes, and finally estimation of myelin water fraction. Other possible correction steps are marked as “optional”.