Akira Yamamoto1, Tsutomu Tamada2, Yu Ueda3, Takeshi Fukunaga2, and Atsushi Higaki2
1Radiology, Kawasaki Medical School, Kurashiki, Japan, 2Kawasaki Medical School, Kurashiki, Japan, 3Phillips Japan, Tokyo, Japan
1Radiology, Kawasaki Medical School, Kurashiki, Japan, 2Kawasaki Medical School, Kurashiki, Japan, 3Phillips Japan, Tokyo, Japan
This study suggests the possibility that
MRI using the values of T2 in cortex and T2* in medulla, which can sensitively
capture edematous changes in the renal cortex and hypoxia in renal medulla, can
be used to evaluate early diabetic nephropathy non-invasively and in a short
period of time.
Recent studies of MR imaging have shown that water content level of tissue could be evaluated sensitively with T2 mapping 1). Steady-state free precession (SSFP) with spatially selective inversion recovery (ss IR) pulse using multi inversion time (TI) is able to distinct renal corticomedullary differentiation
In
two-group comparisons, significant differences were seen between group 0 and
group 1 in values of T2 (mean ± SD: 95.8±8.39 vs. 106.4±11.49; p=0.015) T2* (33.4±2.41 vs. 38.3.0±6.31;
p=0.020), inverted TI (1205±49.4 vs. 1288±55.3; p=0.001) and optimal TI (1367±61.2
vs. 1450±60.0; p=0.002). Significant differences were seen between group 0 and group
2 in values of T2 (95.8±8.39 vs. 105.7±6.38; p=0.021) T2* (33.4±2.41 vs. 41.4±4.69;
p=0.001)