Quan Tao1, Peiwei Yi1, Zimeng Cai1, Yingjie Mei2, Ruiyuan Liu1, and Yanqiu Feng1
1School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 2Philips healthcare, Guangzhou, China
1School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 2Philips healthcare, Guangzhou, China
In
this study, we aimed to use mitochondria target contrast agents (TPP-TEMPOL) to
alleviate the
damage of AKI and monitor the T1 changes by MR scanner. The result confirmed
that TPP-TEMPOL can protect from the injure induce by ROS.
Figure 2. T1-map
of mouse’s kidney in group of Control + Saline (Figure 2a), Control + TPP-TEMPOL
(Figure 2b), AKI + Saline (Figure 2c), AKI + TPP-TEMPOL (Figure 2d).
Figure 4. BUN
measurement (Figure 4a), Booy weight loss (Figure 4b) of four group. Figure 4c
and 4d is the H&E stain for untreated and treated AKI kidney.