Ying Cui1, Tian-yu Tang2, and Shenghong Ju1
1Department of Radiology, Zhongda hospital, Southeast University, Nanjing, China, 2Southeast University, Nanjing, China
1Department of Radiology, Zhongda hospital, Southeast University, Nanjing, China, 2Southeast University, Nanjing, China
T2DM patients showed disrupted interhemispheric
coordination, especially in the occipital lobe. These disruptions are strongly
correlated with insulin resistance, which might be an important treatment
target to abate the cognitive decline in diabetic subjects.
Figure 2. Tractography
results in representative subjects and group differences. The fibers connecting bilateral occipital lobes
in T2DM representative (A) were slender and more diffusely orientated compared
with the healthy controls (B). ** indicates P <0.01, *** indicates P
<0.001.
Figure 3. Correlations between insulin
resistance and the diffusion measures of the occipital fibers. Note
that no such correlations were observed in the
control group. The first row displays the occipital fibers derived from the HCP1021-1mm
template (https://pitt.app.box.com/v/HCP1021-1mm).