Shihui Zhou1,2, Huilou Liang2,3, Yuchao Liang4, Siqi Cai1,2, Chunxiang Jiang1,2, Rong Xue2,3, Lei Wang4, and Lijuan Zhang*1
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2University of Chinese Academy of Sciences, Beijing, China, 3State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 4Neurosurgery, Beijing Tiantan Hospital of Capital Medical University, Beijing, China
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2University of Chinese Academy of Sciences, Beijing, China, 3State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 4Neurosurgery, Beijing Tiantan Hospital of Capital Medical University, Beijing, China
Venous and OEF distribution of the brain varies with the malignant grade of glioma. Low grade gliomas induce more extensive interhemispheric difference in venous and OEF distribution. Oxygenation changes were found coupled with altered venous distribution in brains with high grade glioma.
Figure
1. Maps of
vein density and OEF for representative low grade (LGG), high grade glioma (HGG) cases and control subject.
Figure
2. Differential venous and OEF distribution
based on AAL atlas. # *indicate significant interhemispheric
difference of vein density(VD) and OEF in LGGs; ^ + indicate significant interhemispheric difference of VD and OEF in HGGs, resepectively (paired t
test, p<0.05, FDR corrected).