Tracy Ssali1,2, Lucas Narciso1,2, Matthais Günther3, Frank Prato1,2, Udunna Anazodo1,2, Elizabeth Finger4, and Keith St Lawrence1,2
1Lawson Health Research Institute, London, ON, Canada, 2Department of Medical Biophysics, Western University, London, ON, Canada, 3Fraunhofer Institute for Medical Image Computing MEVIS, Bremen, Germany, 4Department of Clinical Neurological Sciences, Western University, London, ON, Canada
1Lawson Health Research Institute, London, ON, Canada, 2Department of Medical Biophysics, Western University, London, ON, Canada, 3Fraunhofer Institute for Medical Image Computing MEVIS, Bremen, Germany, 4Department of Clinical Neurological Sciences, Western University, London, ON, Canada
Longitudinal variability in perfusion among frontotemporal dementia patients and healthy controls was assessed on a voxel-by-voxel basis over a month. Power analysis revealed ASL has the sensitivity to longitudinal changes as low as 7-8%.
Figure 1: Perfusion averaged over all healthy controls and an exemplary dementia patient participant with semantic variant primary progressive aphasia (svPPA). White arrows indicate regional perfusion deficits.
Figure 3: Within-session and between-session coefficient of variation maps in healthy controls and FTD patients using absolute and relative perfusion.